Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) (Synonyms: Lys-Nε-MCC-DM1) |
| Catalog No.GC33500 |
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) (Lys-Nε-MCC-DM1) es un componente de carga Útil del enlazador que tiene el potencial de inhibir la polimerizaciÓn de tubulina. Lys-SMCC-DM1 (Lys-Nε -MCC-DM1) es el metabolito activo de T-DM1. T-DM1 es un ADC dirigido al receptor 2 del factor de crecimiento epidérmico humano (HER2) con un inhibidor de polimerizaciÓn de tubulina DM1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1281816-04-3
Sample solution is provided at 25 µL, 10mM.
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Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is an FDA approved HER2-targeting ADC.
[1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.
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