Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) (Synonyms: Lys-Nε-MCC-DM1) |
| カタログ番号GC33500 |
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) (Lys-Nε-MCC-DM1) は、チューブリンの重合を阻害する可能性のあるリンカー ペイロード コンポーネントです。 -MCC-DM1) は、T-DM1 の活性代謝物です。 T-DM1 は、チューブリン重合阻害剤 DM1 を含む、ヒト上皮成長因子受容体 2 (HER2) を標的とする ADC です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1281816-04-3
Sample solution is provided at 25 µL, 10mM.
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Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is an FDA approved HER2-targeting ADC.
[1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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