MAK683-CH2CH2COOH |
| Catalog No.GC63056 |
MAK683-CH2CH2COOH se une a EED (proteÍna de desarrollo del ectodermo embrionario). MAK683-CH2CH2COOH y un ligando VHL para la ligasa de ubiquitina E3 se han utilizado para diseÑar el degradador-1 de PROTAC EED y el degradador-2 de PROTAC EED.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2639882-68-9
Sample solution is provided at 25 µL, 10mM.
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MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 and PROTAC EED degrader-2 [1].
MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].
[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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