MAK683-CH2CH2COOH |
| Katalog-Nr.GC63056 |
MAK683-CH2CH2COOH bindet an EED (embryonales Ektoderm-Entwicklungsprotein). MAK683-CH2CH2COOH und ein VHL-Ligand fÜr die E3-Ubiquitin-Ligase wurden verwendet, um PROTAC EED-Degrader-1 und PROTAC EED-Degrader-2 zu entwickeln.
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Cas No.: 2639882-68-9
Sample solution is provided at 25 µL, 10mM.
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MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 and PROTAC EED degrader-2 [1].
MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].
[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
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