ML198 |
| Catalog No.GC64507 |
ML198 es un modulador de glucocerebrosidasa (GCasa) con un EC50 de 0,4 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1380716-06-2
Sample solution is provided at 25 µL, 10mM.
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ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1].
ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts[1].ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1].
[1]. Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase.
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