ML198 |
| Catalog No.GC64507 |
ML198은 EC50이 0.4μM인 글루코세레브로시다제(GCase) 조절제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1380716-06-2
Sample solution is provided at 25 µL, 10mM.
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ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1].
ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts[1].ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1].
[1]. Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase.
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