ML324 (Synonyms: CID-44143209) |
| Catalog No.GC12557 |
ML324 es un potente inhibidor de la desmetilasa JMJD2 con actividad antiviral. ML324 también exhibe inhibiciÓn de la histona desmetilasa KDM4B, con un IC50 de 4,9 μM. ML324 tiene una potente actividad antiviral contra la infecciÓn por el virus del herpes simple (HSV) y el citomegalovirus humano (hCMV) a través de la inhibiciÓn de la expresiÓn del gen viral IE.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1222800-79-4
Sample solution is provided at 25 µL, 10mM.
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ML324 is a potent and cell-permeable JMJD2 demethylase inhibitor (IC50 = 920 nM). [1]
Jumonji-domain-containing proteins (JMJD) is the largest class of N ε -methyl lysine demethylase, an enzyme that demethylates the tri-methylated H3K9. JMJD takes part in gene transcription regulation. [1]
ML324 acted as an antiviral agent that effectively inhibited HSV and hCMV IE gene expression in HFF and MRC-5 cells, resulted in suppression of HSV plaques formation and inhibition of HSV infection spread. [1]
ML324 also blocked HSV-1 reactivation and inhibited the formation of HSV plaque in mouse ganglia explant model of latently infected mice. [1]
References:
1.Rai G, Kawamura A, Tumber A, Liang Y, Vogel JL, Arbuckle JH, Rose NR,
Dexheimer TS, Foley TL, King ON, Quinn A, Mott BT, Schofield CJ, Oppermann U,Jadhav A, Simeonov A, Kristie TM, Maloney DJ. Discovery of ML324, a JMJD2
demethylase inhibitor with demonstrated antiviral activity. 2012 Dec 17 [updated 2013 Sep 16]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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