NH2-C4-NH-Boc |
| Catalog No.GC39114 |
NH2-C4-NH-Boc (compuesto 15) es un conector PROTAC, que se refiere a la composiciÓn de alquilo/éter. NH2-C4-NH-Boc se puede utilizar en la sÍntesis de una serie de PROTAC. Los PROTAC contienen dos ligandos diferentes conectados por un enlazador; uno es un ligando para una ubiquitina ligasa E3 y el otro es para la proteÍna diana. Los PROTAC aprovechan el sistema intracelular de ubiquitina-proteasoma para degradar selectivamente las proteÍnas diana.
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Cas No.: 68076-36-8
Sample solution is provided at 25 µL, 10mM.
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NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.
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