OB 24 hydrochloride |
| Catalog No.GC50348 |
El clorhidrato de OB 24 es un potente inhibidor de la hemooxigenasa-1 (HO-1). La hemooxigenasa-1, miembro de la familia de proteÍnas de choque térmico, desempeÑa un papel clave como sensor y regulador del estrés oxidativo. El clorhidrato de OB 24 inhibiÓ significativamente la proliferaciÓn celular in vitro y el crecimiento tumoral y las metÁstasis en los ganglios linfÁticos/pulmones in vivo. El clorhidrato de OB 24 tiene potencial para la investigaciÓn del cÁncer de prÓstata avanzado (PCA).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 939825-12-4
Sample solution is provided at 25 µL, 10mM.
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Potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol .
Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID:19808972
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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