OB 24 hydrochloride |
| Catalog No.GC50348 |
OB 24 hydrochloride is a potent inhibitor of heme oxygenase-1 (HO-1). Heme oxygenase-1, a member of the heat shock protein family, plays a key role as a sensor and regulator of oxidative stress. OB 24 hydrochloride significantly inhibited cell proliferation in vitro and tumor growth and lymph node/lung metastases in vivo. OB 24 hydrochloride has potential for the research of advanced prostate cancer (PCA).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 939825-12-4
Sample solution is provided at 25 µL, 10mM.
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Potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol .
Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID:19808972
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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