OB 24 hydrochloride |
| Katalog-Nr.GC50348 |
OB 24-Hydrochlorid ist ein starker Inhibitor der HÄmoxygenase-1 (HO-1). Die HÄmoxygenase-1, ein Mitglied der Familie der Hitzeschockproteine, spielt eine SchlÜsselrolle als Sensor und Regulator von oxidativem Stress. OB 24-Hydrochlorid hemmte signifikant die Zellproliferation in vitro und das Tumorwachstum und Lymphknoten-/Lungenmetastasen in vivo. OB 24-Hydrochlorid hat Potenzial fÜr die Erforschung von fortgeschrittenem Prostatakrebs (PCA).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 939825-12-4
Sample solution is provided at 25 µL, 10mM.
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Potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol .
Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID:19808972
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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