P1075 |
| Catalog No.GC16848 |
P1075 es un potente activador de los canales de potasio sensibles al ATP asociados al receptor de sulfonilurea 2 (SUR2-KIR6), con un valor EC50 de 45 nM para la activación del canal SUR2B-KIR6.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60559-98-0
Sample solution is provided at 25 µL, 10mM.
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P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].
References:
[1]. Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17(19):5529-35.
[2]. Oldenburg O, et al. P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35(9):1035-42.
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