Pelitrexol (AG 2037) |
| Catalog No.GC33188 |
Pelitrexol (AG 2037) (AG 2037) es un inhibidor de la glicinamida ribonucleÓtido formiltransferasa (GARFT), una enzima biosintética de purina. Pelitrexol (AG 2037) también inhibe mTORC1 al reducir el nivel de Rheb unido a GTP, un activador obligado de mTORC1. Pelitrexol (AG 2037) muestra una fuerte supresiÓn del crecimiento tumoral en ratones.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 446022-33-9
Sample solution is provided at 25 µL, 10mM.
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Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).
[1]. Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27;19(13):2665-2680.
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