Pelitrexol (AG 2037) |
| Catalog No.GC33188 |
Pelitrexol (AG 2037) (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol (AG 2037) also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol (AG 2037) shows robust tumor growth suppression in mice.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 446022-33-9
Sample solution is provided at 25 µL, 10mM.
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Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).
[1]. Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27;19(13):2665-2680.
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