Pelitrexol (AG 2037) |
| Katalog-Nr.GC33188 |
Pelitrexol (AG 2037) (AG 2037) ist ein Inhibitor der Glycinamid-Ribonukleotid-Formyltransferase (GARFT), einem Enzym der Purin-Biosynthese. Pelitrexol (AG 2037) hemmt auch mTORC1, indem es den GTP-gebundenen Rheb-Spiegel, einen mTORC1-obligatorischen Aktivator, reduziert. Pelitrexol (AG 2037) zeigt eine robuste UnterdrÜckung des Tumorwachstums bei MÄusen.
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Cas No.: 446022-33-9
Sample solution is provided at 25 µL, 10mM.
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Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT).
[1]. Emmanuel N, et al. Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase. Cell Rep. 2017 Jun 27;19(13):2665-2680.
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