Pixantrone-d8 (maleate) |
Catalog No.GC52455 |
An internal standard for the quantification of pixantrone
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Pixantrone-d8 is intended for use as an internal standard for the quantification of pixantrone by GC- or LC-MS. Pixantrone is a DNA topoisomerase II inhibitor.1 It induces SV40 DNA cleavage in the presence of mouse topoisomerase II and induces DNA single-strand breaks in NCI H187 cells in a concentration-dependent manner. Pixantrone is cytotoxic to L1210 leukemia cells as well as doxorubicin-sensitive and -resistant LoVo colon adenocarcinoma cells (IC50 = 0.01, 0.24, and 7.2 µg/ml, respectively).2 It decreases disease severity in a rat model of myasthenia gravis induced by immunization with the T. californica acetylcholine receptor (AChR) when administered at a dose of 8.12 mg/kg once per week for six weeks.3 Formulations containing pixantrone have been used in the treatment of non-Hodgkin B cell lymphoma.
1.De Isabella, P., Palumbo, M., Sissi, C., et al.Topoisomerase II DNA cleavage stimulation, DNA binding activity, cytotoxicity, and physico-chemical properties of 2-aza- and 2-aza-oxide-anthracenedione derivativesMol. Pharmacol.48(1)30-38(1995) 2.Krapcho, A.P., Petry, M.E., Getahun, Z., et al.6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A novel class of chromophore-modified antitumor anthracene-9,10-diones: Synthesis and antitumor evaluationsJ. Med. Chem.37(6)828-837(1994) 3.Marolda, R., Ruocco, C., Cordiglieri, C., et al.Differential targeting of immune-cells by Pixantrone in experimental myasthenia gravisJ. Neuroimmunol.258(1-2)(2013)
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *