Propargyl-PEG5-amine |
| Catalog No.GC64322 |
La propargil-PEG5-amina es un enlazador de ADC no escindible que se utiliza en la sÍntesis de conjugados de anticuerpo y fÁrmaco (ADC). Propargyl-PEG5-amine es un conector PROTAC basado en PEG que se puede utilizar en la sÍntesis de PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1589522-46-2
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.
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