Propargyl-PEG5-amine |
| Katalog-Nr.GC64322 |
Propargyl-PEG5-Amin ist ein nicht spaltbarer ADC-Linker, der bei der Synthese von AntikÖrper-Wirkstoff-Konjugaten (ADCs) verwendet wird. Propargyl-PEG5-Amin ist ein PEG-basierter PROTAC-Linker, der bei der Synthese von PROTACs verwendet werden kann.
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Cas No.: 1589522-46-2
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.
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