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Inicio >> Signaling Pathways >> Cell Cycle/Checkpoint >> Cytoskeleton & Motor Proteins

Cytoskeleton & Motor Proteins

Products for  Cytoskeleton & Motor Proteins

  1. Cat.No. Nombre del producto Información
  2. GC41268 (E)-2-Hexadecenal

    trans-2-Hexadecenal

     Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal Chemical Structure
  3. GC41701 (E)-2-Hexadecenal Alkyne (E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe. (E)-2-Hexadecenal Alkyne Chemical Structure
  4. GC41719 (R)-nitro-Blebbistatin

    R(-)7Desmethyl8nitro Blebbistatin

     (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. (R)-nitro-Blebbistatin Chemical Structure
  5. GC41557 (S)-3'-amino Blebbistatin

    (-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin

     (S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-3'-amino Blebbistatin Chemical Structure
  6. GC41484 (S)-3'-hydroxy Blebbistatin

    (-)-3'-hydroxy Blebbistatin, meta-hydroxy-Blebbistatin, m-hydroxy-Blebbistatin

     (S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-3'-hydroxy Blebbistatin Chemical Structure
  7. GC52192 (S)-4'-nitro-Blebbistatin

    (-)-4'-nitro-Blebbistatin, p-nitro-Blebbistatin, para-nitro-Blebbistatin

     (S)-4'-nitro-Blebbistatin es un inhibidor de miosina II no citotÓxico, fotoestable, fluorescente y especÍfico, utilizado en el estudio del papel especÍfico de la miosina II en estudios fisiolÓgicos, de desarrollo y biolÓgicos celulares. (S)-4'-nitro-Blebbistatin Chemical Structure
  8. GC41739 (S)-nitro-Blebbistatin

    S(-)7Desmethyl8nitro Blebbistatin

     (S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-nitro-Blebbistatin Chemical Structure
  9. GC49736 10-acetyl Docetaxel

    PNU 101383, 10-acetyl Taxotere

     10-acetyl Docetaxel (10-Acetyl docetaxel) es un anÁlogo de Docetaxel, con actividad anticancerÍgena. Docetaxel es un inhibidor del desensamblaje de microtÚbulos, con actividad antimitÓtica. 10-acetyl Docetaxel Chemical Structure
  10. GC41110 16-epi Latrunculin B 16-epi Latrunculin B, first isolated from the Red Sea sponge N. 16-epi Latrunculin B Chemical Structure
  11. GC48423 19-O-Acetylchaetoglobosin A

    Chaetoglobosin A Acetate

     La 19-O-acetilquetoglobosina A, un alcaloide del citocalasano, es un metabolito fÚngico aislado originalmente de C. globosum que tiene actividades inhibidoras de la polimerizaciÓn de actina y citotÓxicas. La 19-O-acetilquetoglobosina A es citotÓxica para las células de cÁncer de cuello uterino HeLa. 19-O-Acetylchaetoglobosin A Chemical Structure
  12. GC52029 2-Aminoflubendazole

    Hydrolyzed Flubendazole

     El 2-aminoflubendazol es el metabolito de los bencimidazoles. 2-Aminoflubendazole Chemical Structure
  13. GC49244 4-oxo Isotretinoin

    Ro 22-6595

     An active metabolite of isotretinoin 4-oxo Isotretinoin Chemical Structure
  14. GC63958 6α-Hydroxy Paclitaxel-d5 6α-Hydroxy Paclitaxel-d5 es el deuterio etiquetado como 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel es un metabolito primario de Paclitaxel. 6α-Hydroxy paclitaxel conserva un efecto dependiente del tiempo sobre los polipéptidos transportadores de aniones orgÁnicos 1B1/SLCO1B1 (OATP1B1) con una potencia de inhibiciÓn similar a Paclitaxel, mientras que ya no mostrÓ inhibiciÓn dependiente del tiempo de OATP1B3. 6α-Hydroxy paclitaxel se puede utilizar para la investigaciÓn del cÁncer. 6α-Hydroxy Paclitaxel-d5 Chemical Structure
  15. GC48721 6-O-Demethyl Griseofulvin

    6-Demethylgriseofulvin

     A metabolite of griseofulvin 6-O-Demethyl Griseofulvin Chemical Structure
  16. GC40844 9-(2,2-Dicyanovinyl)julolidine

    DCVJ, 9-Julolidine Methylene Malononitrile, NSC 160064

     La 9-(2,2-Dicianovinil)julolidina (9-(2,2-Dicianovinil)julolidina), un rotor molecular y un tinte fluorescente Único, se une a la tubulina y la actina y aumenta drÁsticamente la intensidad de su fluorescencia tras la polimerizaciÓn. 9-(2,2-Dicyanovinyl)julolidine Chemical Structure
  17. GC25025 Abraxane

    Nab-Paclitaxel

     Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Abraxane Chemical Structure
  18. GC18274 Amiprofos-methyl

    APM, NSC 313446

     El amiprofos-metilo (BAY-NTN 6867) es un herbicida de amida fosfórica. Amiprofos-methyl Chemical Structure
  19. GC25075 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)

    Antibiotic C 15003P3

     Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM. Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Chemical Structure
  20. GC42933 Binucleine 2 Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. Binucleine 2 Chemical Structure
  21. GC18408 BML-278 BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. BML-278 Chemical Structure
  22. GC46946 BPC 157 (acetate)

    GEPPPGKPADDAGLV, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

     A pentadecapeptide with diverse biological activities BPC 157 (acetate) Chemical Structure
  23. GC45395 Cabazitaxel-d9

    XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9

     Cabazitaxel-d9 es cabazitaxel marcado con deuterio. Cabazitaxel es un derivado semisintético del taxoide natural 10-desacetilbacatina III con potencial actividad antineoplÁsica. Cabazitaxel-d9 Chemical Structure
  24. GC43135 Cambendazol

    Isopropyl 2-(4-thiazolyl)-5-benzimidazolecarbamate, MK-905, NSC 377071

     Cambendazol es uno de los agentes mÁs efectivos para la terapia de estrongiloidiasis humana y . Cambendazol Chemical Structure
  25. GC40890 CAY10701 CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). CAY10701 Chemical Structure
  26. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)L(Cit)DLYEEEMRELRRQ, Biotin-GQGKSXLXDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (G146R) (R144 + R146)-biotin

     A biotinylated and citrullinated mutant vimentin peptide Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide Chemical Structure
  27. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)LGDLYEEEMRELRRQ, Biotin-GQGKSXLGDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (R144)-biotin

     A biotinylated and citrullinated vimentin peptide Citrullinated Vimentin (R144) (139-159)-biotin Peptide Chemical Structure
  28. GC40664 Colcemid

    Demecolcine, NSC 3096

     Colcemid es un inhibidor del citoesqueleto que induce el arresto mitótico en la fase G2/M o el arresto meiótico en la fase de ruptura de vesículas (GVBD) en células de mamíferos u ovocitos, respectivamente. Colcemid Chemical Structure
  29. GC47117 Colchicine-d6 La colchicina-d6 es la colchicina marcada con deuterio. La colchicina es un inhibidor de la tubulina y un agente disruptor de los microtÚbulos. La colchicina inhibe la polimerizaciÓn de microtÚbulos con una IC50 de 3 nM. La colchicina también es un antagonista competitivo de los receptores de glicina α3 (GlyR). Colchicine-d6 Chemical Structure
  30. GC60120 Danicamtiv

    MYK-491, SAR440181

     Danicamtiv (MYK-491), un agente inotrÓpico, es un activador alostérico selectivo de la miosina cardÍaca. Danicamtiv aumenta la funciÓn sistÓlica cardÍaca y preserva la eficiencia mecÁnica. Danicamtiv Chemical Structure
  31. GC49913 Davunetide (acetate)

    AL-108, NAP, NAPVSIPQ

     A neuroprotective ADNP-derived peptide Davunetide (acetate) Chemical Structure
  32. GC43469 Diminutol

    NG72

     Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. Diminutol Chemical Structure
  33. GC48968 Docetaxel (hydrate)

    DTX, NSC 628503, RP 56976, Taxotel

    An analog of taxol with antitumor properties

     Docetaxel (hydrate) Chemical Structure
  34. GC47250 Docetaxel-d9

    DTX-d9, Taxotel-d9

     Docetaxel-d9 (RP-56976-d9) es el docetaxel etiquetado con deuterio. Docetaxel (RP-56976) es un inhibidor de la despolimerizaciÓn de microtÚbulos, con una IC50 de 0,2 μM. Docetaxel atenÚa los efectos de la expresiÓn de los genes bcl-2 y bcl-xL. Docetaxel detiene el ciclo celular en G2/M y conduce a la apoptosis celular. El docetaxel tiene actividad anticancerÍgena. Docetaxel-d9 Chemical Structure
  35. GC49124 EN219 EN219 es un ligando covalente sintético moderadamente selectivo frente a una cisteÍna N-terminal (C8) de RNF114 con una IC50 de 470 nM. EN219 inhibe la autoubiquitinaciÓn mediada por RNF114 y la ubiquitinaciÓn de p21. EN219 Chemical Structure
  36. GC48720 Griseofulvic Acid

    (±)-Griseofulvic Acid

     A metabolite of griseofulvin Griseofulvic Acid Chemical Structure
  37. GC48688 Griseofulvin-d3 An internal standard for the quantification of griseofulvin Griseofulvin-d3 Chemical Structure
  38. GC90733 Klotho-derived Peptide 1 (56-87) (human) (trifluoroacetate salt)

    Un péptido disruptor de TGF-β

     Klotho-derived Peptide 1 (56-87) (human) (trifluoroacetate salt) Chemical Structure
  39. GC90981 Lipid 10

    Un lípido catiónico ionizable.

     Lipid 10 Chemical Structure
  40. GC40048 MPS1/TTK Inhibitor MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. MPS1/TTK Inhibitor Chemical Structure
  41. GC74326 MPSD TFA

    MARCKS-ED TFA

     MPSD TFA (MARCKS-ED TFA) es la forma de sal de TFA de MPSD. MPSD TFA Chemical Structure
  42. GC41564 MPT0B014 An inhibitor of tubulin polymerization MPT0B014 Chemical Structure
  43. GC18445 N-Deacetylcolchicine

    NSC 201400

     An inhibitor of microtubule polymerization N-Deacetylcolchicine Chemical Structure
  44. GC90669 Negamycin (hydrochloride)

    Un antibiótico

     Negamycin (hydrochloride) Chemical Structure
  45. GC49404 Paclitaxel C

    Taxol C, Taxuyunnanine A

     A taxoid and an inhibitor of microtubule depolymerization Paclitaxel C Chemical Structure
  46. GC45944 para-amino-Blebbistatin

    (-)-4'-amino-Blebbistatin, p-amino-Blebbistatin, (S)-4'-amino-Blebbistatin

    Una forma más estable y menos fototóxica de (-)-blebbistatina con una mayor solubilidad en agua.

     para-amino-Blebbistatin Chemical Structure
  47. GC44618 Phalloidin-AMCA Conjugate

    Phalloidin-Aminomethylcoumarin Conjugate

     Phalloidin-AMCA conjugate is a blue fluorophore that specifically labels filamentous actin (F-actin). Phalloidin-AMCA Conjugate Chemical Structure
  48. GC44619 Phalloidin-Fluorescein Conjugate Phalloidin-fluorescein conjugate is a green fluorophore that specifically labels filamentous actin (F-actin). Phalloidin-Fluorescein Conjugate Chemical Structure
  49. GC44620 Phalloidin-Tetramethylrhodamine Conjugate Phalloidin-retramethylrhodamine conjugate is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. Phalloidin-Tetramethylrhodamine Conjugate Chemical Structure
  50. GC48394 Phomopsinamine

    Phomopsinamine A

     An inhibitor of microtubule polymerization Phomopsinamine Chemical Structure
  51. GC49077 Podophyllotoxin-d6

    PPT-d6

     An internal standard for the quantification of podophyllotoxin and picropodophyllotoxin Podophyllotoxin-d6 Chemical Structure
  52. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist Quininib Chemical Structure
  53. GC91096 S-72

    Un inhibidor de la polimerización de microtúbulos.

     S-72 Chemical Structure
  54. GC48090 Sphingosine-d9 (d18:1)

    D-erythro-Sphingosine C18-d9

     A neuropeptide with diverse biological activities Sphingosine-d9 (d18:1) Chemical Structure
  55. GC91228 SSE1806

    Un desestabilizador de microtúbulos.

     SSE1806 Chemical Structure
  56. GC45688 STX140

    2-Methoxyestradiol-bis-sulphamate

     An estrogen sulfamate STX140 Chemical Structure
  57. GC48119 Suprafenacine

    SML1493

     An inhibitor of tubulin polymerization with anticancer activity Suprafenacine Chemical Structure
  58. GC44976 Swinholide A Swinholide A es el policétido marino que se une a la actina y dimeriza la actina con una Kd de ~ 50 nM. Swinholide A Chemical Structure
  59. GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate)

    Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2

     An actin-sequestering peptide Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) Chemical Structure
  60. GC18763 TN-16

    NSC 239274

     TN-16 es un potente inhibidor de la polimerizaciÓn de microtÚbulos con IC50 de 0,4-1,7 μM. TN-16 Chemical Structure
  61. GC52364 Vimentin (139-159)-biotin Peptide

    VIM (139-159)-biotin

     A biotinylated vimentin peptide Vimentin (139-159)-biotin Peptide Chemical Structure
  62. GC52371 Vimentin (G146R) (139-159)-biotin Peptide

    Biotin-GQGKSRLRDLYEEEMRELRRQ, Biotin-GQGKSRLRDLYEEEMRELRRQ (X=Citrulline), VIM (G146R) (139-159)-biotin

     A biotinylated mutant vimentin peptide Vimentin (G146R) (139-159)-biotin Peptide Chemical Structure
  63. GC45595 Vulpinic Acid

    NSC 5897

     El Ácido vulpÍnico, un metabolito del liquen, disminuye la producciÓn de ROS inducida por H2O2, el estrés oxidativo y los daÑos relacionados con el estrés oxidativo en las células endoteliales de la vena umbilical humana (HUVEC). Vulpinic Acid Chemical Structure
  64. GC18578 YK-3-237 YK-3-237, un activador de SIRT1, se dirige al mutante p53. YK-3-237 inhibe la proliferaciÓn de células de cÁncer de mama triple negativas. YK-3-237 Chemical Structure

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