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Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> Cytoskeleton & Motor Proteins

Cytoskeleton & Motor Proteins

Products for  Cytoskeleton & Motor Proteins

  1. Cat.No. Product Name Information
  2. GC41268 (E)-2-Hexadecenal

    trans-2-Hexadecenal

     Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal Chemical Structure
  3. GC41701 (E)-2-Hexadecenal Alkyne (E)-2-Hexadecenal alkyne is an alkyne version of the sphingolipid degradation product (E)-2-hexadecenal that can be used as a click chemistry probe. (E)-2-Hexadecenal Alkyne Chemical Structure
  4. GC41719 (R)-nitro-Blebbistatin

    R(-)7Desmethyl8nitro Blebbistatin

     (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin, which is the inactive form of (-)-blebbistatin. (R)-nitro-Blebbistatin Chemical Structure
  5. GC41557 (S)-3'-amino Blebbistatin

    (-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin

     (S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-3'-amino Blebbistatin Chemical Structure
  6. GC41484 (S)-3'-hydroxy Blebbistatin

    (-)-3'-hydroxy Blebbistatin, meta-hydroxy-Blebbistatin, m-hydroxy-Blebbistatin

     (S)-3'-hydroxy Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-3'-hydroxy Blebbistatin Chemical Structure
  7. GC52192 (S)-4'-nitro-Blebbistatin

    (-)-4'-nitro-Blebbistatin, p-nitro-Blebbistatin, para-nitro-Blebbistatin

     (S)-4'-nitro-Blebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies. (S)-4'-nitro-Blebbistatin Chemical Structure
  8. GC41739 (S)-nitro-Blebbistatin

    S(-)7Desmethyl8nitro Blebbistatin

     (S)-nitro-Blebbistatin is a more stable form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (S)-nitro-Blebbistatin Chemical Structure
  9. GC49736 10-acetyl Docetaxel

    PNU 101383, 10-acetyl Taxotere

     10-acetyl Docetaxel (10-Acetyl docetaxel) is an analog of Docetaxel, with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity. 10-acetyl Docetaxel Chemical Structure
  10. GC41110 16-epi Latrunculin B 16-epi Latrunculin B, first isolated from the Red Sea sponge N. 16-epi Latrunculin B Chemical Structure
  11. GC48423 19-O-Acetylchaetoglobosin A

    Chaetoglobosin A Acetate

     A fungal metabolite with actin polymerization inhibitory and cytotoxic activities 19-O-Acetylchaetoglobosin A Chemical Structure
  12. GC52029 2-Aminoflubendazole

    Hydrolyzed Flubendazole

     2-Aminoflubendazole Chemical Structure
  13. GC49244 4-oxo Isotretinoin

    Ro 22-6595

     An active metabolite of isotretinoin 4-oxo Isotretinoin Chemical Structure
  14. GC63958 6α-Hydroxy Paclitaxel-d5 6α-Hydroxy Paclitaxel-d5 is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer. 6α-Hydroxy Paclitaxel-d5 Chemical Structure
  15. GC48721 6-O-Demethyl Griseofulvin

    6-Demethylgriseofulvin

     A metabolite of griseofulvin 6-O-Demethyl Griseofulvin Chemical Structure
  16. GC40844 9-(2,2-Dicyanovinyl)julolidine

    DCVJ, 9-Julolidine Methylene Malononitrile, NSC 160064

     9-(2,2-Dicyanovinyl)julolidine (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. 9-(2,2-Dicyanovinyl)julolidine Chemical Structure
  17. GC25025 Abraxane

    Nab-Paclitaxel

     Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Abraxane Chemical Structure
  18. GC18274 Amiprofos-methyl

    APM, NSC 313446

     Amiprofos-methyl (APM) is a phosphoric amide herbicide. Amiprofos-methyl Chemical Structure
  19. GC25075 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)

    Antibiotic C 15003P3

     Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM. Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) Chemical Structure
  20. GC42933 Binucleine 2 Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. Binucleine 2 Chemical Structure
  21. GC18408 BML-278 BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. BML-278 Chemical Structure
  22. GC46946 BPC 157 (acetate)

    GEPPPGKPADDAGLV, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

     A pentadecapeptide with diverse biological activities BPC 157 (acetate) Chemical Structure
  23. GC45395 Cabazitaxel-d9

    XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9

     Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d9 Chemical Structure
  24. GC43135 Cambendazol

    Isopropyl 2-(4-thiazolyl)-5-benzimidazolecarbamate, MK-905, NSC 377071

     Cambendazol is one of the most effective agents for the therapy of human strongyloidiasis and . Cambendazol Chemical Structure
  25. GC40890 CAY10701 CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). CAY10701 Chemical Structure
  26. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)L(Cit)DLYEEEMRELRRQ, Biotin-GQGKSXLXDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (G146R) (R144 + R146)-biotin

     A biotinylated and citrullinated mutant vimentin peptide Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide Chemical Structure
  27. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)LGDLYEEEMRELRRQ, Biotin-GQGKSXLGDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (R144)-biotin

     A biotinylated and citrullinated vimentin peptide Citrullinated Vimentin (R144) (139-159)-biotin Peptide Chemical Structure
  28. GC40664 Colcemid

    Demecolcine, NSC 3096

     Colcemid is a cytoskeletal inhibitor that induces mitotic arrest in the G2/M phase or meiotic arrest in the vesicle rupture (GVBD) phase in mammalian cells or oocytes, respectively. Colcemid Chemical Structure
  29. GC47117 Colchicine-d6

    An internal standard for the quantification of colchicine

     Colchicine-d6 Chemical Structure
  30. GC60120 Danicamtiv

    MYK-491, SAR440181

    Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.

     Danicamtiv Chemical Structure
  31. GC49913 Davunetide (acetate)

    AL-108, NAP, NAPVSIPQ

     A neuroprotective ADNP-derived peptide Davunetide (acetate) Chemical Structure
  32. GC43469 Diminutol

    NG72

     Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. Diminutol Chemical Structure
  33. GC48968 Docetaxel (hydrate)

    DTX, NSC 628503, RP 56976, Taxotel

    An analog of taxol with antitumor properties

     Docetaxel (hydrate) Chemical Structure
  34. GC47250 Docetaxel-d9

    DTX-d9, Taxotel-d9

    An internal standard for the quantification of docetaxel

     Docetaxel-d9 Chemical Structure
  35. GC49124 EN219 EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 Chemical Structure
  36. GC48720 Griseofulvic Acid

    (±)-Griseofulvic Acid

     A metabolite of griseofulvin Griseofulvic Acid Chemical Structure
  37. GC48688 Griseofulvin-d3 An internal standard for the quantification of griseofulvin Griseofulvin-d3 Chemical Structure
  38. GC90733 Klotho-derived Peptide 1 (56-87) (human) (trifluoroacetate salt)

    A TGF-β disrupting peptide

     Klotho-derived Peptide 1 (56-87) (human) (trifluoroacetate salt) Chemical Structure
  39. GC90981 Lipid 10

    An ionizable cationic lipid

     Lipid 10 Chemical Structure
  40. GC40048 MPS1/TTK Inhibitor MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. MPS1/TTK Inhibitor Chemical Structure
  41. GC74326 MPSD TFA

    MARCKS-ED TFA

     MPSD TFA (MARCKS-ED TFA) is the TFA salt form of MPSD. MPSD TFA Chemical Structure
  42. GC41564 MPT0B014 An inhibitor of tubulin polymerization MPT0B014 Chemical Structure
  43. GC18445 N-Deacetylcolchicine

    NSC 201400

     An inhibitor of microtubule polymerization N-Deacetylcolchicine Chemical Structure
  44. GC90669 Negamycin (hydrochloride)

    An antibiotic

     Negamycin (hydrochloride) Chemical Structure
  45. GC49404 Paclitaxel C

    Taxol C, Taxuyunnanine A

     A taxoid and an inhibitor of microtubule depolymerization Paclitaxel C Chemical Structure
  46. GC45944 para-amino-Blebbistatin

    (-)-4'-amino-Blebbistatin, p-amino-Blebbistatin, (S)-4'-amino-Blebbistatin

     A more stable and less phototoxic form of (–)-blebbistatin with enhanced water solubility para-amino-Blebbistatin Chemical Structure
  47. GC44618 Phalloidin-AMCA Conjugate

    Phalloidin-Aminomethylcoumarin Conjugate

     Phalloidin-AMCA conjugate is a blue fluorophore that specifically labels filamentous actin (F-actin). Phalloidin-AMCA Conjugate Chemical Structure
  48. GC44619 Phalloidin-Fluorescein Conjugate Phalloidin-fluorescein conjugate is a green fluorophore that specifically labels filamentous actin (F-actin). Phalloidin-Fluorescein Conjugate Chemical Structure
  49. GC44620 Phalloidin-Tetramethylrhodamine Conjugate Phalloidin-retramethylrhodamine conjugate is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. Phalloidin-Tetramethylrhodamine Conjugate Chemical Structure
  50. GC48394 Phomopsinamine

    Phomopsinamine A

     An inhibitor of microtubule polymerization Phomopsinamine Chemical Structure
  51. GC49077 Podophyllotoxin-d6

    PPT-d6

     An internal standard for the quantification of podophyllotoxin and picropodophyllotoxin Podophyllotoxin-d6 Chemical Structure
  52. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist Quininib Chemical Structure
  53. GC91096 S-72

    An inhibitor of microtubule polymerization

     S-72 Chemical Structure
  54. GC48090 Sphingosine-d9 (d18:1)

    D-erythro-Sphingosine C18-d9

     A neuropeptide with diverse biological activities Sphingosine-d9 (d18:1) Chemical Structure
  55. GC91228 SSE1806

    A microtubule destabilizer

     SSE1806 Chemical Structure
  56. GC45688 STX140

    2-Methoxyestradiol-bis-sulphamate

     An estrogen sulfamate STX140 Chemical Structure
  57. GC48119 Suprafenacine

    SML1493

     An inhibitor of tubulin polymerization with anticancer activity Suprafenacine Chemical Structure
  58. GC44976 Swinholide A

    Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.

     Swinholide A Chemical Structure
  59. GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate)

    Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2

     An actin-sequestering peptide Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) Chemical Structure
  60. GC18763 TN-16

    NSC 239274

     TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM). TN-16 Chemical Structure
  61. GC52364 Vimentin (139-159)-biotin Peptide

    VIM (139-159)-biotin

     A biotinylated vimentin peptide Vimentin (139-159)-biotin Peptide Chemical Structure
  62. GC52371 Vimentin (G146R) (139-159)-biotin Peptide

    Biotin-GQGKSRLRDLYEEEMRELRRQ, Biotin-GQGKSRLRDLYEEEMRELRRQ (X=Citrulline), VIM (G146R) (139-159)-biotin

     A biotinylated mutant vimentin peptide Vimentin (G146R) (139-159)-biotin Peptide Chemical Structure
  63. GC45595 Vulpinic Acid

    NSC 5897

       Vulpinic Acid Chemical Structure
  64. GC18578 YK-3-237 An inhibitor of tubulin polymerization and activator of SIRT1 YK-3-237 Chemical Structure

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