Chromatin/Epigenetics
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Epigenetics
Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.
Research Areas
- Bromodomain(44)
- Aurora Kinase(74)
- DNA Methyltransferase(43)
- HDAC(250)
- Histone Acetyltransferases(100)
- Histone Demethylases(120)
- Histone Methyltransferase(278)
- HIF(127)
- JAK(190)
- PARP(162)
- Pim(35)
- Protein Ser/Thr Phosphatases(23)
- RNA Polymerase(4)
- Sirtuin(88)
- Sphingosine Kinase-2(1)
- Polycomb repressive complex(2)
- SUMOylation(3)
- PAD(20)
- Epigenetic Reader Domain(295)
- MicroRNA(33)
- Protein Arginine Deiminase(17)
- Chromodomain(1)
- Citrullination(20)
- DNA/RNA Demethylation(2)
- DNA/RNA Methylation(8)
- Histone Deacetylation(43)
- Histones/Histone Peptides(62)
- PHD Domains(1)
- Tandem Tudor & Tudor-like Domains(1)
- PRMT(2)
- Readers(1)
- Small Interfering RNA (siRNA)(16)
- METTL3(4)
- WDR5(8)
- TET Protein(2)
- HuR(2)
- SF3B1(2)
Products Related to Chromatin/Epigenetics(1948)
- GC68711AZ13824374Purity: >98.00%
AZ13824374 es un inhibidor selectivo y eficiente de ATAD2 que tiene actividad anti-proliferativa en el cáncer de mama. En las pruebas de detección FRET y NanoBRET de ATAD2, AZ13824374 muestra pIC50 de 8.2 y 6.2, respectivamente.
- GC68795Bomedemstat dihydrochloridePurity: >99.00%
Bomedemstat (IMG-7289) dihidrocloruro es un inhibidor irreversible de la lisina-específica demetilasa 1 (LSD1) con actividad oral. Bomedemstat dihidrocloruro puede aumentar la metilación de H3K4 y H3K9, lo que luego altera la expresión génica. Bomedemstat dihidrocloruro tiene actividad anticancerígena, puede inhibir la proliferación celular del cáncer e inducir apoptosis.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC67863 | DDO-2093 dihydrochloride | - | >98.00% | |
| GC67867 | VVD-118313 | 2875046-27-6 | >98.00% | |
| GC67873 | PAD-IN-2 | 2304852-21-7 | >98.00% | |
| GC67899 | Aurora kinase inhibitor-8 | 2133001-88-2 | >98.00% | |
| GC67906 | OM-153 | 2406278-81-5 | >98.00% | |
| GC67912 | Amredobresib | 1610044-98-8 | >98.00% | |
| GC67921 | Bomedemstat ditosylate | 1990504-72-7 | >98.00% | |
| GC67934 | EEDi-5285 | 2488952-40-3 | >98.00% | |
| GC67941 | HIF-PHD-IN-1 | 1567657-46-8 | >98.00% | |
| GC67962 | Simmiparib | 1551355-46-4 | >98.00% | |
| GC67984 | Alteminostat | 1246374-97-9 | >98.00% | |
| GC68000 | JAK-IN-23 | - | >98.00% | |
| GC68006 | PARP1-IN-11 | 2482484-87-5 | >98.00% | |
| GC68010 | HDAC3-IN-T247 | 1451042-18-4 | >98.00% | |
| GC68025 | UNC1021 | 1322591-19-4 | >96.00% | |
| GC68035 | PARP10/15-IN-1 | - | >98.00% | |
| GC68147 | dAURK-4 hydrochloride | - | >98.00% | |
| GC68161 | 5-AIQ | 93117-08-9 | >99.00% | |
| GC68378 | GDC-4379 | 2252277-73-7 | >98.00% | |
| GC68405 | Lys-CoA TFA | - | >98.00% | |
| GC68439 | GNE-064 | 1997321-20-6 | >98.00% | |
| GC68474 | Pivanex | 122110-53-6 | >98.00% | |
| GC68711 | AZ13824374 | - | >98.00% | |
AZ13824374 es un inhibidor selectivo y eficiente de ATAD2 que tiene actividad anti-proliferativa en el cáncer de mama. En las pruebas de detección FRET y NanoBRET de ATAD2, AZ13824374 muestra pIC50 de 8.2 y 6.2, respectivamente. | ||||
| GC68795 | Bomedemstat dihydrochloride | - | >99.00% | |
Bomedemstat (IMG-7289) dihidrocloruro es un inhibidor irreversible de la lisina-específica demetilasa 1 (LSD1) con actividad oral. Bomedemstat dihidrocloruro puede aumentar la metilación de H3K4 y H3K9, lo que luego altera la expresión génica. Bomedemstat dihidrocloruro tiene actividad anticancerígena, puede inhibir la proliferación celular del cáncer e inducir apoptosis. | ||||