HCN Channel
Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.
HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.
Targets for HCN Channel
Products for HCN Channel
- Cat.No. Nombre del producto Información
- GC18503 DK-AH 269 La cilobradina es un bloqueador del canal HCN; un bloqueador de canales abiertos de Ih neuronal y canales If cardÍacos relacionados.
- GC32491 Zatebradine (UL-FS49) La zatebradina (UL-FS49) (UL-FS-49 (base libre); UL-FS-49CL (base libre)) es un potente inhibidor de los canales dependientes de nucleÓtidos cÍclicos (HCN) activados por hiperpolarizaciÓn con un valor IC50 de 1,96 μ ;METRO.
- GC16965 Zatebradine hydrochloride La zatebradina (UL-FS-49 (base libre)) es un potente inhibidor de los canales dependientes de nucleÓtidos cÍclicos (HCN) activados por hiperpolarizaciÓn con valores de IC50 de 1,96 μM.
- GC10578 ZD 7288 ZD 7288 (ICI D7288) es un bloqueador de canales selectivo de nucleótidos cíclicos activados por hiperpolarización (HCN).