HCN Channel
Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.
HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.
Targets for HCN Channel
Products for HCN Channel
- Cat.No. Product Name Information
- GC18503 DK-AH 269 Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
- GC32491 Zatebradine (UL-FS49) Zatebradine (UL-FS49) (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 μM.
- GC16965 Zatebradine hydrochloride hyperpolarization-activated current If (HCN channel) inhibitor
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GC10578
ZD 7288
HCN channel inhibitor