HCN Channel

Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.

HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.

Targets for HCN Channel

Products for HCN Channel

Cat.No. Product Name Information
GC68799 BPU-11
BPU-11 is a ligand for the hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) of HCN4 CLP. It can be used in research on congenital immune diseases.
GC18503 DK-AH 269

Cilobradine
Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
GC73927 KIO-301 chloride (hydrochloride) KIO-301 chloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including perpolarization-activated cyclic nucleotide gating and voltage-gated potassium channels.
GC32491 Zatebradine (UL-FS49) Zatebradine (UL-FS49) (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 μM.
GC16965 Zatebradine hydrochloride

UL-FS 49
hyperpolarization-activated current If (HCN channel) inhibitor
GC10578 ZD 7288

ICI-D 7288

HCN channel inhibitor