Ribociclib D6 (Synonyms: LEE011-d6) |
| Catalog No.GC60324 |
Ribociclib D6 (LEE011 D6) es un ribociclib marcado con deuterio. Ribociclib es un inhibidor de CDK4/6 altamente específico con valores IC50 de 10 nM y 39 nM, respectivamente, y es 1000 veces menos potente contra el complejo ciclina B/CDK1.
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Cas No.: 1328934-40-2
Sample solution is provided at 25 µL, 10mM.
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Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.
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