RIPK1-IN-4 |
| Catalog No.GC38841 |
RIPK1-IN-4 (compuesto 8) es un inhibidor potente y selectivo de la quinasa de tipo II de la quinasa de la proteÍna 1 que interactÚa con el receptor (RIP1) y se une a una forma inactiva de RIP1 sin DLG con una IC50 de 16 nM y 10 nM para RIP1 y ADP-Glo quinasa.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1481641-08-0
Sample solution is provided at 25 µL, 10mM.
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RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].
[1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.
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