RIPK1-IN-4 |
| カタログ番号GC38841 |
RIPK1-IN-4 (化合物 8) は、受容体相互作用タンパク質 1 (RIP1) キナーゼの強力かつ選択的なタイプ II キナーゼ阻害剤であり、RIP1 に対して 16 nM および 10 nM の IC50 で RIP1 の DLG-out 不活性型に結合し、 ADP-Gloキナーゼ。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1481641-08-0
Sample solution is provided at 25 µL, 10mM.
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RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1].
[1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.
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