Rosuvastatin D3 (Synonyms: ZD 4522 D3) |
| Catalog No.GC61251 |
La rosuvastatina D3 (ZD 4522 D3) es una rosuvastatina marcada con deuterio.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1133429-16-9
Sample solution is provided at 25 µL, 10mM.
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Rosuvastatin D3 (ZD 4522 D3) is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].
[1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [2]. Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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