(S)-Bromoenol lactone (Synonyms: (S)BEL) |
| Catalog No.GC40679 |
La (S)-bromoenol lactona ((S)-BEL) es un inhibidor irreversible, quiral, basado en un mecanismo de la fosfolipasa A2β independiente del calcio (iPLA2β) que inhibe la liberaciÓn de araquidonato inducida por vasopresina a partir de mÚsculo liso aÓrtico de rata en cultivo (A10) células con una IC50 de 2 μM.
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Cas No.: 478288-94-7
Sample solution is provided at 25 µL, 10mM.
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The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM. (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.
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