SIRT7 inhibitor 97491 |
Catalog No.GC60338 |
El inhibidor de SIRT7 97491, un potente inhibidor de SIRT7 con una IC50 de 325 nM, reduce la actividad desacetilasa de SIRT7 en una manera dependiente de la dosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1807758-81-1
Sample solution is provided at 25 µL, 10mM.
SIRT7 inhibitor 97491 is a potent SIRT 7 inhibitor that reduces the deacetylase activity of SIRT7 in a dose-dependent manner with an IC50 of 325 nM. SIRT7 inhibitor 97491 increases p53 stability through acetylation at K373/382. In addition, SIRT7 inhibitor 97491 promotes cell apoptosis through the caspase pathway[1].
In vitro, treatment with SIRT7 inhibitor 97491 (5 µM, 10 µM) for 72 hours resulted in a reduction of MES-SA cell proliferation by more than 50% without causing toxic effects on HEK 293 cells[1].
In vivo, three weeks of treatment with SIRT7 inhibitor 97491 (20 mg/kg/day; i.p.) inhibited tumor growth in xenograft mice[1].
References:
[1] Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.
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