SIRT7 inhibitor 97491 |
Catalog No.GC60338 |
SIRT7 억제제 97491은 IC50 값이 325 nM인 강력한 SIRT7 억제제로, 용량 의존적으로 SIRT7의 탈아세틸화 효소 활동을 감소시킵니다.
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Cas No.: 1807758-81-1
Sample solution is provided at 25 µL, 10mM.
SIRT7 inhibitor 97491 is a potent SIRT 7 inhibitor that reduces the deacetylase activity of SIRT7 in a dose-dependent manner with an IC50 of 325 nM. SIRT7 inhibitor 97491 increases p53 stability through acetylation at K373/382. In addition, SIRT7 inhibitor 97491 promotes cell apoptosis through the caspase pathway[1].
In vitro, treatment with SIRT7 inhibitor 97491 (5 µM, 10 µM) for 72 hours resulted in a reduction of MES-SA cell proliferation by more than 50% without causing toxic effects on HEK 293 cells[1].
In vivo, three weeks of treatment with SIRT7 inhibitor 97491 (20 mg/kg/day; i.p.) inhibited tumor growth in xenograft mice[1].
References:
[1] Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.
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