Sphinganine-1-phosphate (d18:0) (Synonyms: C18-dihydro Sphingosine-1-phosphate, D-erythro-Sphinganine-1-phosphate, dihydro-D-erythro-Sphingosine-1-phosphate) |
Catalog No.GC44927 |
La esfinganina-1-fosfato (d18:0) (D-eritro-dihidroesfingosina 1-fosfato) es un metabolito de esfingolÍpido polar que regula la migraciÓn celular, la diferenciaciÓn, la supervivencia y procesos fisiolÓgicos complejos.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19794-97-9
Sample solution is provided at 25 µL, 10mM.
Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively. It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.
Average Rating: 5
(Based on Reviews and 21 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *