Sphinganine-1-phosphate (d18:0) (Synonyms: C18-dihydro Sphingosine-1-phosphate, D-erythro-Sphinganine-1-phosphate, dihydro-D-erythro-Sphingosine-1-phosphate) |
| Catalog No.GC44927 |
Sphinganine-1-phosphate (d18:0) (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes.
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Cas No.: 19794-97-9
Sample solution is provided at 25 µL, 10mM.
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Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively. It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.
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