Tat-ASIC1a (1-20) (mouse, rat) (trifluoroacetate salt) (Synonyms: NT1-20; Tat-Acid-sensing Ion Channel 1a (1-20)) |
| Catalog No.GC91479 |
Tat-ASIC1a (1-20) es un péptido sintético compuesto por la secuencia de péptido que penetra en la célula del dominio de transducción de proteína Tat del VIH-1, unida a un péptido de 20 aminoácidos correspondiente a los aminoácidos 1-20 del canal iónico sensor ácido 1a (ASIC1a).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Tat-ASIC1a (1-20) is a synthetic peptide composed of the cell-penetrating peptide sequence from the HIV-1 Tat protein transduction domain linked to a 20-amino acid peptide corresponding to amino acids 1-20 of acid-sensing ion channel 1a (ASIC1a).1 It prevents acid-induced association of ASIC1a with receptor-interacting serine/threonine kinase 1 (RIPK1) and necroptosis in primary mouse cortical neurons when used at a concentration of 10 µM. Tat-ASIC1a (1-20) decreases infarct volume in a mouse model of ischemia induced by middle cerebral artery occlusion (MCAO).
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