Tat-ASIC1a (1-20) (mouse, rat) (trifluoroacetate salt) (Synonyms: NT1-20; Tat-Acid-sensing Ion Channel 1a (1-20)) |
| Catalog No.GC91479 |
Tat-ASIC1a (1-20)는 HIV-1 Tat 단백질 수송 도메인의 세포 침투 펩타이드 서열과 ASIC1a (산성 감지 이온 채널 1a)의 아미노산 1-20에 해당하는 20개 아미노산 펩타이드가 연결된 합성 펩타이드입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Tat-ASIC1a (1-20) is a synthetic peptide composed of the cell-penetrating peptide sequence from the HIV-1 Tat protein transduction domain linked to a 20-amino acid peptide corresponding to amino acids 1-20 of acid-sensing ion channel 1a (ASIC1a).1 It prevents acid-induced association of ASIC1a with receptor-interacting serine/threonine kinase 1 (RIPK1) and necroptosis in primary mouse cortical neurons when used at a concentration of 10 µM. Tat-ASIC1a (1-20) decreases infarct volume in a mouse model of ischemia induced by middle cerebral artery occlusion (MCAO).
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