Tat-ASIC1a (1-20) (mouse, rat) (trifluoroacetate salt) (Synonyms: NT1-20; Tat-Acid-sensing Ion Channel 1a (1-20)) |
| Katalog-Nr.GC91479 |
Tat-ASIC1a (1-20) ist ein synthetisches Peptid, das aus der zellpenetrierenden Peptidsequenz des HIV-1 Tat-Proteintransduktionsdomäne und einem 20-Aminosäuren-Peptid besteht, das den Aminosäuren 1-20 des sauren Sensorkanals 1a (ASIC1a) entspricht.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Tat-ASIC1a (1-20) is a synthetic peptide composed of the cell-penetrating peptide sequence from the HIV-1 Tat protein transduction domain linked to a 20-amino acid peptide corresponding to amino acids 1-20 of acid-sensing ion channel 1a (ASIC1a).1 It prevents acid-induced association of ASIC1a with receptor-interacting serine/threonine kinase 1 (RIPK1) and necroptosis in primary mouse cortical neurons when used at a concentration of 10 µM. Tat-ASIC1a (1-20) decreases infarct volume in a mouse model of ischemia induced by middle cerebral artery occlusion (MCAO).
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