TX1-85-1 |
| Catalog No.GC34847 |
TX1-85-1 es un inhibidor irreversible de Her3 (ErbB3) con una IC50 de 23 nM. TX1-85-1 es también el primer ligando selectivo de Her3, que forma un enlace covalente con Cys721 ubicado en el sitio de uniÓn de ATP de Her3. TX1-85-1 induce la degradaciÓn parcial de la proteÍna Her3 y atenÚa la seÑalizaciÓn dependiente de Her3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1603845-32-4
Sample solution is provided at 25 µL, 10mM.
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TX1-85-1 is a Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1]. ErbB3|23 nM (IC50)
[1]. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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