TX1-85-1 |
カタログ番号GC34847 |
TX1-85-1 は、IC50 が 23 nM の不可逆的な Her3 (ErbB3) 阻害剤です。 TX1-85-1 は、Her3 の ATP 結合部位にある Cys721 と共有結合を形成する最初の選択的 Her3 リガンドでもあります。 TX1-85-1 は、Her3 タンパク質の部分分解を誘導し、Her3 依存性シグナル伝達を弱めます。
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Cas No.: 1603845-32-4
Sample solution is provided at 25 µL, 10mM.
TX1-85-1 is a Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1]. ErbB3|23 nM (IC50)
[1]. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.
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