Viridicatol |
| Catalog No.GC45147 |
Viridicatol, un alcaloide de quinolinona, se aÍsla de la fermentaciÓn de un hongo endÓfito Penicillium sp.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14484-44-7
Sample solution is provided at 25 µL, 10mM.
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Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma. It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells. It also inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B α (IκBα) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay. It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 μM).
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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