WAY 181187 oxalate (Synonyms: SAX-187 oxalate) |
| Catalog No.GC50213 |
El oxalato WAY-181187 (SAX-187) es un agonista completo del receptor 5-HT6 potente y selectivo con una Ki de 2,2 nM y una EC50 de 6,6 nM.
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Cas No.: 1883548-85-3
Sample solution is provided at 25 µL, 10mM.
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High affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.
Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID:25837696 |Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID:17948978
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