WAY 181187 oxalate (Synonyms: SAX-187 oxalate) |
| Katalog-Nr.GC50213 |
WAY-181187 (SAX-187) Oxalat ist ein potenter und selektiver 5-HT6-Rezeptor-Agonist mit einem Ki von 2,2 nM und einem EC50 von 6,6 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1883548-85-3
Sample solution is provided at 25 µL, 10mM.
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High affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.
Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID:25837696 |Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID:17948978
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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