WT IDH1 Inhibitor 2 |
| Catalog No.GC64359 |
El inhibidor 2 de WT IDH1 (compuesto 3) es un inhibidor de isocitrato deshidrogenasa 1 (WT IDH1) de tipo salvaje con un valor IC50 de 120 nM. El inhibidor 2 de WT IDH1 como inhibidor R132H IDH1 mutante es un isÓmero de GSK321 con cierta reactividad cruzada de tipo salvaje.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1816272-19-1
Sample solution is provided at 25 µL, 10mM.
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WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].
WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].
[1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.
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