WT IDH1 Inhibitor 2 |
| Catalog No.GC64359 |
WT IDH1 Inhibitor 2 (Composé 3) est un inhibiteur de l'isocitrate déshydrogénase 1 (WT IDH1) de type sauvage avec une valeur IC50 de 120 nM. WT IDH1 Inhibitor 2 en tant qu'inhibiteur mutant R132H IDH1, est un isomère de GSK321 avec une certaine réactivité croisée de type sauvage.
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Cas No.: 1816272-19-1
Sample solution is provided at 25 µL, 10mM.
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WT IDH1 Inhibitor 2 (Compound 3) is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].
WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].
[1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.
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