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YCH1899

Catalog No.GC91435 Copy One-Click Copy Product Info

YCH1899 es un inhibidor de la poli(ADP-ribosa) polimerasa 1 (PARP1) y PARP2 (IC50s = 1). Es selectivo para PARP1 y PARP2 sobre PARP3, -4, -5A, -5B, -6, -7, -10 y -12 (IC50s = 1-14.1 nM).

Products are for research use only. Not for human use. We do not sell to patients.

YCH1899 Chemical Structure

Tamaño Precio Disponibilidad Cantidad
10mM (in 1mL DMSO)
218,00 $
Disponible
5mg
180,00 $
Disponible
10mg
293,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.



Description of YCH1899

YCH1899 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1 It is selective for PARP1 and PARP2 over PARP3, -4, -5A, -5B, -6, -7, -10, and -12 (IC50s = 1-14.1 nM). YCH1899 inhibits the proliferation of Capan-1 cells (IC50 = 0.1 nM), as well as Capan-1 cells resistant to the PARP inhibitors talazoparib (BMN 673; ) or olaparib (; IC50s = 1.13 and 0.89 nM, respectively). It inhibits the proliferation of BRCA1 mutant HCC1937 breast cancer cells (IC50 = 4.54 nM). In vivo, YCH1899 (12.5 and 25 mg/kg) reduces tumor growth in an olaparib-resistant MDA-MB-436 breast cancer mouse xenograft model.

Chemical Properties of YCH1899

Cas No. SDF
Formula C25H18BrFN6O3 M.Wt 549.4
Solubility DMSO: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of YCH1899

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.8202 mL 9.1008 mL 18.2017 mL
5 mM 364 μL 1.8202 mL 3.6403 mL
10 mM 182 μL 910.1 μL 1.8202 mL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution) of YCH1899

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for YCH1899

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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