Bergaptol (5-Hydroxypsoralen) |
| رقم الكتالوجGC33909 |
Bergaptol (5-Hydroxypsoralen) هو سورالين الهيدروكسيل الذي يعمل كمثبطات فعالة لنشاط إزالة الإنزيم من إنزيم CYP3A4 بقيمة IC50 تبلغ 24.92 ميكرومتر.
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Cas No.: 486-60-2
Sample solution is provided at 25 µL, 10mM.
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BergaptolA hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties.target: CYP3A4 [1]IC50: 24.92 [1]For in vivo enzyme activity analysis, 100 μM bergaptol was added to the cultures for an additional 24 h at 37°C. After centrifugation, the supernatant was used to measure the bergapten yield by high performance liquid chromatography (HPLC).[2]
[1]. Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691 [2]. Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722.
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