>>Lipids>> P450>>Bergaptol (5-Hydroxypsoralen)

Bergaptol (5-Hydroxypsoralen)

Catalog No.GC33909

Bergaptol(5-Hydroxypsoralen)은 24.92 uM의 IC50 값을 갖는 CYP3A4 효소의 탈벤질화 활성의 강력한 억제제로 작용하는 수산화 소랄렌입니다.

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Bergaptol (5-Hydroxypsoralen) Chemical Structure

Cas No.: 486-60-2

Size 가격 재고 수량
10mM (in 1mL DMSO)
US$158.00
재고 있음
500mg
US$143.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

BergaptolA hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties.target: CYP3A4 [1]IC50: 24.92 [1]For in vivo enzyme activity analysis, 100 μM bergaptol was added to the cultures for an additional 24 h at 37°C. After centrifugation, the supernatant was used to measure the bergapten yield by high performance liquid chromatography (HPLC).[2]

[1]. Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691 [2]. Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722.

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