BRM/BRG1 ATP Inhibitor-1 (Synonyms: Brahma Homologue/Brahma-related Gene 1 Adenosine 5'-triphosphate Inhibitor 1) |
| رقم الكتالوجGC34891 |
BRM / BRG1 ATP Inhibitor-1 (المركب 14) هو متماثل خيفي مزدوج نشط عن طريق الفم (BRM) / SWI / SNF مرتبط بمصفوفة معتمدة على الأكتين لعائلة الكروماتين الفرعية عضو 2 (SMARCA2) والجين 1 المرتبط ببراهما (BRG1) / مثبط نشاط SMARCA4 ATPase ، كلا من IC50s أقل من 0.005 ميكرومترBRM / BRG1 ATP Inhibitor-1 له نشاط مضاد للسرطان
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Cas No.: 2270879-17-7
Sample solution is provided at 25 µL, 10mM.
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BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1]. IC50: ﹤0.005 µM (BRM, BRG1)[1]
Reference:
[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
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