BRM/BRG1 ATP Inhibitor-1 (Synonyms: Brahma Homologue/Brahma-related Gene 1 Adenosine 5'-triphosphate Inhibitor 1) |
| Katalog-Nr.GC34891 |
BRM/BRG1 ATP-Inhibitor-1 (Verbindung 14) ist ein oral aktiver allosterischer dualer Brahma-Homolog (BRM)/SWI/SNF-verwandter Matrix-assoziierter Aktin-abhÄngiger Regulator von Chromatin-Unterfamilie A Mitglied 2 (SMARCA2) und Brahma-verwandtes Gen 1 (BRG1)/ SMARCA4 ATPase-AktivitÄtsinhibitor, beide IC50-Werte liegen unter 0,005 μM. BRM/BRG1 ATP Inhibitor-1 hat AntikrebsaktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2270879-17-7
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1]. IC50: ﹤0.005 µM (BRM, BRG1)[1]
Reference:
[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *