BRM/BRG1 ATP Inhibitor-1 (Synonyms: Brahma Homologue/Brahma-related Gene 1 Adenosine 5'-triphosphate Inhibitor 1) |
| カタログ番号GC34891 |
BRM/BRG1 ATP 阻害剤-1 (化合物 14) は、クロマチン サブファミリー A メンバー 2 (SMARCA2) およびブラフマ関連遺伝子 1 (BRG1) のアクチン依存性レギュレーターに関連する経口活性アロステリック デュアル ブラフマ ホモログ (BRM)/SWI/SNF 関連マトリックスです。 SMARCA4 ATPase 活性阻害剤、両方の IC50 は 0.005 μM 未満です。 BRM/BRG1 ATP Inhibitor-1 には抗がん作用があります。
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Cas No.: 2270879-17-7
Sample solution is provided at 25 µL, 10mM.
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BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1]. IC50: ﹤0.005 µM (BRM, BRG1)[1]
Reference:
[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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