BTSA1 |
| Catalog No.GC39355 |
BTSA1은 250nM의 IC50 및 144nM의 EC50을 갖는 강력하고 높은 친화도 및 경구 활성 BAX 활성제입니다. BTSA1은 N-말단 활성화 부위에 높은 친화성과 특이성으로 결합하고 BAX에 대한 구조적 변화를 유도하여 BAX 매개 세포자멸사를 유도합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 314761-14-3
Sample solution is provided at 25 µL, 10mM.
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BTSA1 is a potent, high affinity and orally active BAX activator with an IC50 of 250 nM and an EC50 of 144 nM. BTSA1 binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis[1].
[1]. Reyna DE, et al. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 Oct 9;32(4):490-505.e10.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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