CAM833 |
| رقم الكتالوجGC65935 |
CAM833 هو مثبط تقويمي قوي للتفاعل بين BRCA2 و RAD51 مع Kd 366 نانومتر ضد بروتين ChimRAD51. يمنع CAM833 أيضًا قلة قلة RAD51.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2758364-02-0
Sample solution is provided at 25 µL, 10mM.
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CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization[1].
CAM833 (3.125-50 μM; 24 h) causes a concentration-dependent decrease in RAD51 foci and subsequent increase in DNA damage[1].
CAM833 (25 μM) inhibits RAD51 molecular clustering at DNA damage sites[1].
CAM833 (0-50 μM) inhibits DNA repair by homologous recombination[1].
CAM833 (20 μM; 0-72 h) potentiates radiation-induced cell-cycle arrest and increases apoptosis over time[1].
CAM833 (10 μM) causes a dose-dependent growth inhibition that is enhanced when combined with ionizing radiation[1].
CAM833 (20 μM; 96 h) potentiates the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells[1].
Cell Cycle Analysis[1]
| Cell Line: | HCT116 cells |
| Concentration: | 20 μM |
| Incubation Time: | 0-72 h |
| Result: | In the control the percentage of cells in the apoptotic subG1 fraction remains below 5% throughout, in the compound-treated cells this rises progressively to peak at 15% at 48 hours. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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